Fig. 2
From: Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data
An example of one round of simulation results (simulation 316) comparing calculated RSD for metabolites in QC and analytical samples before normalization (open circles) and RSD after normalization for four different methods (closed circles) v. true RSD prior to inclusion of batch effects and batch-specific detection thresholds in the simulation. Points are colored according to the proportion of undetected levels in the simulation for that metabolite. The black line indicates perfect correspondence of true and estimated RSD