Fig. 3
From: Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data
A plot of beta estimates from simple no-intercept linear regression models using simulation data. Calculated RSD after normalization was treated as the outcome and true RSD prior to inclusion of batch effects and batch-specific detection thresholds in the simulation was treated as the predictor. A beta value of 1 indicates perfect correspondence with beta values <1 (>1) indicating under- (over-) estimation of RSD by the normalization method. Betas are plotted according to increasing amounts of missing data, i.e. the proportion of simulated undetected values for a given metabolite