Table 1 Set of 36 phenotypes obtained from the listed siRNA experiments sorted by its CMPO identifier
From: How can functional annotations be derived from profiles of phenotypic annotations?
Experiment | Description | Phenotypes | IDs in CMPO |
|---|---|---|---|
CellMorph [3] | Genome-wide RNAi screen that examines changes in the morphology of individual HeLa cells within cell populations. | - Decreased cell number | CMPO:0000052 |
- Cell with projections | CMPO:0000071 | ||
- Elongated cell | CMPO:0000077 | ||
- More lamellipodia cells | CMPO:0000083 | ||
- Increased number of actin filament | CMPO:0000105 | ||
- Round cell | CMPO:0000118 | ||
- Increased cell size | CMPO:0000128 | ||
- Decreased cell size | CMPO:0000129 | ||
- Bright nuclei | CMPO:0000154 | ||
- Metaphase arrested | CMPO:0000305 | ||
- Increased cell size in population | CMPO:0000340 | ||
MitoCheck [2] | Genome-wide RNAi screen for genes required for chromosome segregation in HeLa cells. The screen also reports genes involved in other processes such as cell movement. | - Cell death | CMPO:0000030 |
- Increased nucleus size | CMPO:0000140 | ||
- Graped micronucleus | CMPO:0000156 | ||
- Abnormal nucleus shape | CMPO:0000157 | ||
- Mitosis delayed | CMPO:0000202 | ||
- Binuclear cell | CMPO:0000213 | ||
- Absence of mitotic chromosome decondensation | CMPO:0000216 | ||
- Increased cell movement speed | CMPO:0000236 | ||
- Increased cell movement distance | CMPO:0000237 | ||
- Proliferating cells | CMPO:0000241 | ||
- Metaphase delayed | CMPO:0000307 | ||
- Abnormal chromosome segregation | CMPO:0000326 | ||
- Prometaphase delayed | CMPO:0000344 | ||
- Increased variability of nuclear shape in population | CMPO:0000345 | ||
- Mitotic metaphase plate congression | CMPO:0000348 | ||
EMBL secretion [4] | Genome-wide RNAi screen for interference with ER-to-plasma membrane transport of the secretory cargo protein tsO45G in HeLa cells. | - Increased rate of protein secretion | CMPO:0000246 |
- Mild decrease in rate of protein secretion | CMPO:0000318 | ||
- Strong decrease in rate of protein secretion | CMPO:0000319 | ||
- Decreased rate of intracellular protein transport | CMPO:0000346 | ||
GR00053 [10] | Genome-wide RNAi screen for genes involved in DNA damage responses in HeLa cells. | - Increased number of site of double-strand break | CMPO:0000182 |
GR00290 [9] | Genome-wide RNAi screen for genes regulating centriole formation in HeLa cells. | - Increased centriole replication | CMPO:0000361 |
- Decreased centriole replication | CMPO:0000362 | ||
Copenhagen DNA damage Ubiquitin [8] | RNAi screen of >1300 genes involved in the ubiquitin-proteasome system or encoding zinc-finger proteins looking for modulators of cellular responses to ionizing radiation in HeLa and U2OS cells. | - Decreased number of site of double-strand break | CMPO:0000181 |
EMBL chromosome condensation [7] | RNAi screen of 100 bioinformatically-selected genes for changes in mitotic prophase duration in HeLa cells. | - Increased duration of mitotic prophase | CMPO:0000328 |
- Decreased duration of mitotic prophase | CMPO:0000329 |