Table 4 The mean and standard deviation (in parenthesis) of sensitivity, specificity and area under curve (AUC) calculated for conventional differential gene expression analysis: DEA, dwgLASSO with no prior biological knowledge incorporated: dwgLASSO (no prior), KDDN, and dwgLASSO with prior biological knowledge incorporated: dwgLASSO (prior)
Methods | Testing dataset 1 | Testing dataset 2 | ||||
|---|---|---|---|---|---|---|
| Â | Specificity | Sensitivity | AUC | Specificity | Sensitivity | AUC |
DEA | 0.950 (0.07) | 0.913 (0.06) | 0.951 (0.04) | 0.950 (0.07) | 0.941 (0.04) | 0.983 (0.01) |
dwgLASSO (no prior) | 0 . 9 8 8 ( 0 . 0 3 ) | 0.888 (0.11) | 0.972 (0.02) | 0 . 9 8 8 ( 0 . 0 3 ) | 0.956 (0.05) | 0.990 (0.01) |
KDDN | 0.963 (0.08) | 0 . 9 5 0 ( 0 . 0 4 ) | 0.980 (0.02) | 0.963 (0.08) | 0.939 (0.03) | 0.989 (0.01) |
dwgLASSO (prior) | 0 . 9 8 8 ( 0 . 0 3 ) | 0.950 (0.07) | 0 . 9 8 2 ( 0 . 0 3 ) | 0 . 9 8 8 ( 0 . 0 3 ) | 0 . 9 6 5 ( 0 . 0 3 ) | 0 . 9 9 4 ( 0 . 0 1 ) |