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Table 1 Results for loci reaching genome-wide significance in the multi-phenotype rare variant analysis of NFBC1966 (N = 4,721). Regression coefficients with their standard errors (SE) are reported, followed by the P-value and the Bayesian Information Criterion (BIC) for the analysed model. TG, triglycerides; ln(FI), natural logarithm transformed fasting insulin; WHR, waist-to-hip ratio

From: MARV: a tool for genome-wide multi-phenotype analysis of rare variants

  APOA5
(Chr 11: 116,660,086-116,663,136)
ZNF259
(Chr 11: 116,649,276-116,658,739)
Model β (SE) P-value; BIC β (SE) P-value; BIC
TG + ln(FI) + WHR, full model a   3.32 × 10−8; −19877.3   6.3 × 10−8; −25069.6
 TG 0.011 (0.002) - 0.007 (0.001) -
 ln(FI) −0.010 (0.004) - −0.008 (0.002) -
 WHR 0.027 (0.019) - 0.010 (0.011) -
TG + ln(FI)   2.00 × 10−8; −19883.5   1.8 × 10−9; −25077.3
 TG 0.011 (0.002) - 0.007 (0.001) -
 ln(FI) −0.010 (0.004) - −0.007 (0.002) -
TG + WHR   3.34 × 10−7; −19877.9   4.1 × 10−7; −25066.5
 TG 0.009 (0.002) - 0.005 (0.001) -
 WHR 0.020 (0.019) - 0.005 (0.001) -
ln(FI) + WHR   0.08; −19853.1   0.10; −25427.6
 ln(FI) −0.003 (0.004) - −0.003 (0.002) -
 WHR 0.041 (0.019) - 0.019 (0.011) -
Univariate b
 TG 0.009 (0.002) 9.15 × 10−8; −19885.1 0.005 (0.001) 6.5 × 10−8; −25074.7
 ln(FI) −0.002 (0.003) 0.62; −19856.8 −0.002 (0.002) 0.27; −25046.7
 WHR 0.038 (0.019) 0.04; −19860.7 0.016 (0.011) 0.16; −25047.5
  1. a For a genome-wide joint analysis, the level of significance is P < 1.67 × 10−6 after Bonferroni correction for 30,000 genes
  2. b For univariate analysis, the level of significance is P < 5.56 × 10−7 after Bonferroni correction for 30,000 genes and three phenotypes