Table 1 Results for loci reaching genome-wide significance in the multi-phenotype rare variant analysis of NFBC1966 (N = 4,721). Regression coefficients with their standard errors (SE) are reported, followed by the P-value and the Bayesian Information Criterion (BIC) for the analysed model. TG, triglycerides; ln(FI), natural logarithm transformed fasting insulin; WHR, waist-to-hip ratio
From: MARV: a tool for genome-wide multi-phenotype analysis of rare variants
APOA5 (Chr 11: 116,660,086-116,663,136) | ZNF259 (Chr 11: 116,649,276-116,658,739) | |||
|---|---|---|---|---|
Model | β (SE) | P-value; BIC | β (SE) | P-value; BIC |
TG + ln(FI) + WHR, full model a | 3.32 × 10−8; −19877.3 | 6.3 × 10−8; −25069.6 | ||
TG | 0.011 (0.002) | - | 0.007 (0.001) | - |
ln(FI) | −0.010 (0.004) | - | −0.008 (0.002) | - |
WHR | 0.027 (0.019) | - | 0.010 (0.011) | - |
TG + ln(FI) | 2.00 × 10−8; −19883.5 | 1.8 × 10−9; −25077.3 | ||
TG | 0.011 (0.002) | - | 0.007 (0.001) | - |
ln(FI) | −0.010 (0.004) | - | −0.007 (0.002) | - |
TG + WHR | 3.34 × 10−7; −19877.9 | 4.1 × 10−7; −25066.5 | ||
TG | 0.009 (0.002) | - | 0.005 (0.001) | - |
WHR | 0.020 (0.019) | - | 0.005 (0.001) | - |
ln(FI) + WHR | 0.08; −19853.1 | 0.10; −25427.6 | ||
ln(FI) | −0.003 (0.004) | - | −0.003 (0.002) | - |
WHR | 0.041 (0.019) | - | 0.019 (0.011) | - |
Univariate b | ||||
TG | 0.009 (0.002) | 9.15 × 10−8; −19885.1 | 0.005 (0.001) | 6.5 × 10−8; −25074.7 |
ln(FI) | −0.002 (0.003) | 0.62; −19856.8 | −0.002 (0.002) | 0.27; −25046.7 |
WHR | 0.038 (0.019) | 0.04; −19860.7 | 0.016 (0.011) | 0.16; −25047.5 |