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Fig. 2 | BMC Bioinformatics

Fig. 2

From: 3D: diversity, dynamics, differential testing – a proposed pipeline for analysis of next-generation sequencing T cell repertoire data

Fig. 2

The distribution of the pairwise fold change (FC) between PBMC samples (NeoACT study) for one healthy subject (a, c) and one treated prostate cancer subject (b, d). For clonotype i, FC is calculated by \( F C={ \log}_2\frac{p_{ik}}{p_{ij}} \), where k and j are the samples from two different time points for the same subject. Each curve represents a pair of samples: PBMC.2 vs. PBMC.0 (red), PBMC.4 vs. PBMC.0 (green) and PBMC.4 vs. PBMC.2 (blue). Top figures (a, b) include the clones present at either of the sample from a pair and bottom figures (c, d) include the clones present at both samples from a pair (i.e., the overlap clones)

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BMC Bioinformatics

ISSN: 1471-2105

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