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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Distribution based nearest neighbor imputation for truncated high dimensional data with applications to pre-clinical and clinical metabolomics studies

Fig. 1

Two examples of metabolite distributions which have missing values (MVs), from the myocardial infarction data [15]. The black vertical line on each graph shows the minimum value of the data, considered as the lower limit of detection (LOD). The small vertical lines below the x-axis in each case indicate the observed values of the metabolites. The figure on the top shows the distribution of 1,2 dipalmitoylglycerol, where the observed values are all around three standard deviations above the LOD. In this case, the MVs are likely to be MAR or MCAR. In contrast, the figure on the bottom shows the distribution of 7-ketodeoxycholate, which is close to the LOD. Here, the MVs are likely to be below the LOD and hence MNAR

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