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Fig. 9 | BMC Bioinformatics

Fig. 9

From: Using structural knowledge in the protein data bank to inform the search for potential host-microbe protein interactions in sequence space: application to Mycobacterium tuberculosis

Fig. 9

Interfacial residues mediating a common domain-domain interaction in different complexes do not necessarily line up in the multiple sequence alignment. The displayed alignment corresponds to the Pfam domain Plectin/S10 (PF03501), which is found to interact with the K Homology domain (PF07650) in several PDB complexes. The sequences (domain instances) are labeled by their PDB identifiers (PDB ID, chain ID and residue numbers). The interfacial residues involved in this DDI are highlighted in yellow, and their positions in the alignment show considerable scatter

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