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Fig. 2 | BMC Bioinformatics

Fig. 2

From: Differential correlation analysis of glioblastoma reveals immune ceRNA interactions predictive of patient survival

Fig. 2

Core ceRNA interaction network and its significance in genome-wide gene interaction. a Examples to high- (H-ce-pair), medium- (M-ce-pair), and low- (L-ce-pair) miRNA-optimized ceRNA interaction pairs. Coexpression of two ceRNAs is significantly intensified in the optimized group. b The core ceRNA interaction network. A total of 1,762 core ceRNA triplets were identified by a stringent criterion (Bonferroni adjusted P < 10-5). Node size is proportional to node degree. ceRNAs accounting for more than 1% of edges are labeled with gene symbols. Highlighted in colors are ceRNAs involved in the largest three enriched functions reported by DAVID. c Node degrees of core ceRNAs and other genes in the genome-wide gene coexpression network. Statistical significance of difference is assessed by the Wilcoxon rank sum test. d Proportions of core ceRNAs and other genes appearing as hub genes (with degrees ranked in the top 5%) in the genome-wide interaction network. Statistical significance is assessed by a Fisher’s exact test. e Validation of core ceRNA triplets in CGGA datasets. Interaction scores were compared between the 1,762 core ce-triplets identified in TCGA datasets and other putative triplets by the t-test

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