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Table 1 Amino acid (AA) relative frequency (%) and conservation index (CI)

From: Machine learning classifier for identification of damaging missense mutations exclusive to human mitochondrial DNA-encoded polypeptides

  IM TM M
AA N % CI tM D N % CI tM D N % CI tM D
A 37 5.1 50.4 37 0 192 8.3 57.4 177 7 26 3.5 44.6 27 1
C 3 0.4 67.4 1 0 14 0.6 59.2 8 0 5 0.7 64.5 4 0
D 28 3.8 73.2 25 0 21 0.9 69.8 9 2 17 2.3 72.4 16 0
E 18 2.5 57.5 7 0 42 1.8 78.4 23 2 28 3.8 71.0 15 2
F 30 4.1 60.7 22 0 154 6.7 69.5 104 1 32 4.3 58.3 18 1
G 46 6.3 73.9 25 0 128 5.5 80.8 60 4 38 5.1 77.0 15 0
H 18 2.5 64.6 12 0 51 2.2 74.0 22 1 28 3.8 55.9 26 0
I 45 6.2 44.4 44 0 234 10.1 46.0 318 0 40 5.4 35.5 55 0
K 11 1.5 58.2 1 0 39 1.7 66.2 9 0 45 6.0 45.3 17 0
L 98 13.4 50.1 44 1 457 19.7 60.4 205 12 89 11.9 49.0 46 1
M 31 4.3 52.5 20 2 140 6.1 38.9 134 3 37 5.0 34.1 36 0
N 49 6.7 48.4 49 0 65 2.8 47.7 59 0 50 6.7 44.0 70 0
P 61 8.4 70.9 31 0 90 3.9 65.1 41 2 68 9.1 65.2 41 0
Q 24 3.3 55.9 8 0 35 1.5 63.2 11 1 31 4.2 54.1 20 0
R 10 1.4 86.6 2 0 33 1.4 80.5 14 1 20 2.7 82.6 13 3
S 58 8.0 39.6 55 0 159 6.9 53.1 117 2 57 7.6 42.2 61 2
T 82 11.2 36.3 73 0 207 8.9 40.6 201 0 62 8.3 33.4 79 0
V 33 4.5 49.7 32 0 114 4.9 50.7 147 3 20 2.7 42.0 18 0
W 20 2.7 89.0 1 0 64 2.8 79.9 19 1 20 2.7 71.5 7 0
Y 27 3.7 67.1 17 1 75 3.2 64.9 36 0 33 4.4 43.2 31 1
  729    506 4 2314    1714 42 746    615 11
  1. IM, TM, M, N, tM and D code for intermembrane, transmembrane, and matrix domains, total positions with this amino acid, number of total and damaging mutations, respectively