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Table 1 Amino acid (AA) relative frequency (%) and conservation index (CI)

From: Machine learning classifier for identification of damaging missense mutations exclusive to human mitochondrial DNA-encoded polypeptides

 

IM

TM

M

AA

N

%

CI

tM

D

N

%

CI

tM

D

N

%

CI

tM

D

A

37

5.1

50.4

37

0

192

8.3

57.4

177

7

26

3.5

44.6

27

1

C

3

0.4

67.4

1

0

14

0.6

59.2

8

0

5

0.7

64.5

4

0

D

28

3.8

73.2

25

0

21

0.9

69.8

9

2

17

2.3

72.4

16

0

E

18

2.5

57.5

7

0

42

1.8

78.4

23

2

28

3.8

71.0

15

2

F

30

4.1

60.7

22

0

154

6.7

69.5

104

1

32

4.3

58.3

18

1

G

46

6.3

73.9

25

0

128

5.5

80.8

60

4

38

5.1

77.0

15

0

H

18

2.5

64.6

12

0

51

2.2

74.0

22

1

28

3.8

55.9

26

0

I

45

6.2

44.4

44

0

234

10.1

46.0

318

0

40

5.4

35.5

55

0

K

11

1.5

58.2

1

0

39

1.7

66.2

9

0

45

6.0

45.3

17

0

L

98

13.4

50.1

44

1

457

19.7

60.4

205

12

89

11.9

49.0

46

1

M

31

4.3

52.5

20

2

140

6.1

38.9

134

3

37

5.0

34.1

36

0

N

49

6.7

48.4

49

0

65

2.8

47.7

59

0

50

6.7

44.0

70

0

P

61

8.4

70.9

31

0

90

3.9

65.1

41

2

68

9.1

65.2

41

0

Q

24

3.3

55.9

8

0

35

1.5

63.2

11

1

31

4.2

54.1

20

0

R

10

1.4

86.6

2

0

33

1.4

80.5

14

1

20

2.7

82.6

13

3

S

58

8.0

39.6

55

0

159

6.9

53.1

117

2

57

7.6

42.2

61

2

T

82

11.2

36.3

73

0

207

8.9

40.6

201

0

62

8.3

33.4

79

0

V

33

4.5

49.7

32

0

114

4.9

50.7

147

3

20

2.7

42.0

18

0

W

20

2.7

89.0

1

0

64

2.8

79.9

19

1

20

2.7

71.5

7

0

Y

27

3.7

67.1

17

1

75

3.2

64.9

36

0

33

4.4

43.2

31

1

 

729

  

506

4

2314

  

1714

42

746

  

615

11

  1. IM, TM, M, N, tM and D code for intermembrane, transmembrane, and matrix domains, total positions with this amino acid, number of total and damaging mutations, respectively