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Table 5 Percentage of confirmed and predicted pathologic mutations per polypeptide/complex (A) or domain (B)

From: Machine learning classifier for identification of damaging missense mutations exclusive to human mitochondrial DNA-encoded polypeptides

A
Complex Polypeptide AA % MUT % MUT %
Confirmed Predicted
CI   2214 55.8 36 63.2 7190 47.8
p.MT-ND1 318 8.4 15 26.3 1300 8.6
p.MT-ND2 347 9.2 1 1.8 1032 6.9
p.MT-ND3 115 3.0 2 3.5 420 2.8
p.MT-ND4 459 12.1 3 5.3 1689 11.2
p.MT-ND4L 98 2.6 1 1.8 377 2.5
p.MT-ND5 603 15.9 7 12.3 2008 13.3
p.MT-ND6 174 4.6 7 12.3 364 2.4
CIII   380 10.0 2 3.5 1721 11.4
p.MT-CYB 380 10.0 2 3.5 1721 11.4
CIV   1001 26.4 4 7.0 5146 34.2
p.MT-CO1 513 13.5 1 1.8 2803 18.6
p.MT-CO2 227 6.0 2 3.5 1021 6.8
p.MT-CO3 261 6.9 1 1.8 1322 8.8
CV   294 7.8 15 26.3 992 6.6
p.MT-ATP6 226 6.0 15 26.3 876 5.8
p.MT-ATP8 68 1.8 0 0 116 0.8
B
Domain AA % MUT % MUT %
   Confirmed Predicted
3889 100 57 100 15049 100
IM 747 19.2 4 7.0 2883 19.1
TM 2376 61.1 42 73.7 9294 61.8
M 766 19.7 11 19.3 2872 19.1
  1. Complex, polypeptide, AA, %, MUT, %, confirmed, predicted, IM, TM and M refer to OXPHOS complexes, mtDNA-encoded polypeptides, number of amino acids and its percentage in a particular polypeptide or domain, number of damaging mutations and its percentage in a particular polypeptide or domain, confirmed damaging mutations, predicted damaging mutations by Mitoclass.1, intermembrane, transmembrane and matrix domains, respectively