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Table 2 Most used SLiMs conserved and located in HIV-1 disordered regions

From: Prediction of virus-host protein-protein interactions mediated by short linear motifs

SLiM

#HIV-proteins

Pfam domain

Domain name

LIG_WD40_WDR5_VDV_2

17

IPR017986

WD40-repeat-containing domain

DOC_USP7_1

17

PF00917

MATH domain

CLV_NRD_NRD_1

16

PF00675

Insulinase (Peptidase family M16)

CLV_PCSK_KEX2_1

15

PF00082

Peptidase_S8 Subtilase family

MOD_GSK3_1

15

PF00069

Protein kinase domain

MOD_PIKK_1

15

PF00454

Phosphatidylinositol 3- and 4-kinase

CLV_PCSK_SKI1_1

14

PF00082

Peptidase_S8 Subtilase family

LIG_SH3_3

14

PF00018

SH3 domain

MOD_NEK2_1

13

PF00069

Protein kinase domain

LIG_FHA_2

13

PF00498

FHA domain

MOD_CK1_1

13

PF00069

Protein kinase domain

LIG_FHA_1

12

PF00498

FHA domain

DOC_CYCLIN_1

12

PF00134

Dynein light chain type 1

LIG_LIR_Nem_3

12

PF02991

Autophagy protein Atg8 ubiquitin like

DOC_WW_Pin1_4

12

PF00397

WW domain

MOD_ProDKin_1

12

PF00069

Protein kinase domain

MOD_PKA_2

12

PF00069

Protein kinase domain

MOD_CK2_1

12

PF00069

Protein kinase domain

TRG_ER_diArg_1

12

PF00400

WD domain, G-beta repeat

LIG_SH2_STAT5

11

PF00017

SH2 domain

LIG_LIR_Gen_1

11

PF02991

Autophagy protein Atg8 ubiquitin like

CLV_PCSK_PC1ET2_1

11

PF00082

Peptidase_S8 Subtilase family

MOD_GlcNHglycan

11

PF01048

Phosphorylase superfamily

MOD_N-GLC_1

10

PF02516

Oligosaccharyl transferase STT3 subunit

TRG_ENDOCYTIC_2

10

PF00928

Adaptor complexes medium subunit family

  1. From the SLiMs that are conserved in more than 70% of the HIV-1 protein sequences, and are located in disordered regions too we counted how many HIV-1 proteins include them. In this table we report the SLiMs more commonly used in HIV-1 proteins, the ones that are included in 10 or more of the HIV-1 proteins. The table includes the counter domain for every SLiM