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Fig. 2 | BMC Bioinformatics

Fig. 2

From: Bacterial protein meta-interactomes predict cross-species interactions and protein function

Fig. 2

Consensus meta-interactome. a A breakdown of source species of the meta-interactome shows that PPIs in E. coli or C. jejuni contributed to more than half of the total set of interactions in the meta-interactome. b We defined the pool of interactions between proteins in different bacteria as the meta-interactome. To account for homologous proteins, we considered groups of orthologous proteins (OG) as nodes in a consensus meta-interactome. In particular, we weighted links between OGs by the underlying number of observed interactions between proteins in such groups. c The main component of the consensus meta-interactome pools 88.9% of all OGs. Our graphical depiction suggests that the majority of OGs consist of one protein, while such groups are mostly linked by one underlying PPI. d More quantitatively, we found that the majority of OGs in the consensus meta-interactome indeed have only one protein while a minority of groups includes many proteins. e The distributions of the number of PPI that connect proteins in different OGs (f) as well as the number of neighboring OGs decay as a power-laws

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