Fig. 7

Example of the protein set analysis. Pairwise IAS scores among all protein pairs in the human genome were computed. a, A snap shot of the table of protein pairs in the result page sorted by the IAS score. The color level shows the significance of the scores. b, The fraction of the protein pairs that are actually physically interacting among those above IAS score cutoffs (x-axis). Pairs that have a score of 200 or higher are considered. Physically interacting protein pairs were checked with the BIOGRID database. For example, 100% of pairs that have a score of 850 or higher and 78.5% of pairs with a score of 700 or higher actually interact with each other. c, A network view of the 56 unique proteins from the top high-scoring 33 protein pairs. Protein pairs that have an IAS score of 200 or higher are connected by edges. Protein pairs that have a high IAS score of over 850, 650, and 450, are connected with thick color lines in red, blue, and green. There are three, 19, and 47 such pairs, respectively. Two protein pairs that are discussed in Table 2 are circled. The magenta circle shows an example of physically interacting pairs and the circle in orange shows a functionally similar protein pair that do not physically interact with each other, which is correctly identified with a low IAS. See text for more details