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Fig. 8 | BMC Bioinformatics

Fig. 8

From: NaviGO: interactive tool for visualization and functional similarity and coherence analysis with gene ontology

Fig. 8

Analysing function prediction results with NaviGO. NaviGO is linked from the PFP and ESG function prediction webservers, which predict GO terms for input protein sequence. This example shows function prediction for human aconitate hydrolase (UniProt ID: Q99798). This protein is a moonlighting protein, which has two distinct function, aconitase and involvement of iron homeostatis. a, An output page of ESG. The output page has a link to NaviGO, which is indicated by a red circle in the figure. Clicking this link will send predicted GO terms of the query protein listed below in the table, which has the medium confidence or higher, to NaviGO’s GO Set input page, so that users can further analyse the predicted GO terms. b, Predicted GO terms in the MF category visualized in NaviGO. Color codes shows the confidence of prediction. c, Predicted GO terms in the BP category visualized in NaviGO. d, The network view of the predicted GO terms in NaviGO using the RSS, showing functionally similar GO terms in clusters. GO terms in MF and BP are colored in blue and red, respectively. We see two clusters for MF, indicating that this protein has two distinct functions

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