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Fig. 3 | BMC Bioinformatics

Fig. 3

From: The autophagy interaction network of the aging model Podospora anserina

Fig. 3

Predicted autophagy PPI network of P. anserina with age-dependent expression profiles. The colors of the solid lines indicate the species that exhibits the interaction (green edges for yeast and blue for human). If an interaction was found in both species, the edge is colored purple. In addition, if an interaction was found in the yeast two-hybrid analysis, an edge is colored yellow. For example, an interaction of PaATG8 and PaATG4 was found in yeast and human (purple edge) and additionally in the yeast two-hybrid analysis (yellow). Hence, this interaction is represented by two edges (purple and yellow), since it was found in all three PPI data sources. The nodes are color-coded according to the Pearson correlation coefficient of the corresponding age-dependent expression profiles. The more the expression of a transcript was increased during aging the more red is the node. The opposite direction is colored blue. The red arrows indicate transcripts which were continuously up-regulated during aging according to [34]. Red stars highlight the hub nodes, see Table 1. The number of proteins per module - from module 1 (red) to module 7 (orange) - are depicted in the bar plot in the upper left corner. The grey bar corresponds to proteins which were not assigned to a module, but subsequently added. Nodes, which were grouped to one of the seven functional modules, were discriminated by similar border colors

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