The autophagy interaction network of the aging model Podospora anserina

BMC Bioinformatics

Table 1 Results of the topological analysis

Topology	Pred. net.	Rand. net.	Test statistic	p-value
	(median)
Diameter	8	6	Relative frequencies	0.007
Modularity	0.57	0.32	Shapiro-Wilk + Norm.dist	1.22e−13
Transitivity	0.35	0.12	Shapiro-Wilk + Norm.dist.	2.74e−42
Betweenness	NA	NA	Kolmogorov-Smirnov	1.17e−08
Degrees	NA	NA	Kolmogorov-Smirnov	0.09

Different test procedures were applied according to the corresponding topological feature (see “Methods” section and Additional file 5). The topological values of the predicted network and the median values of the random networks are listed. In addition, the corresponding p-values are shown, indicating the significance of the difference between the random and the predicted network. The computation of a single topological value for transitivity and betweenness was not applicable, since each node of each network has one betweenness and one degree. Here, only the distributions had been compared using the Kolmogorov-Smirnoff test

ISSN: 1471-2105