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Table 2 The ten most important proteins of the predicted PPI network

From: The autophagy interaction network of the aging model Podospora anserina

Module no. Protein Alias (no. Ranks Total Effects in
(color code) identifier of interactions) degree / rank knockout
    between.   yeast strains
3 (turquois) Pa_3_5250 PaATG8 (22) 1 / 1 2 ne, aa, dv
2 (green) Pa_5_5550 PaATG9 (13) 2 / 4 6 ne, aa, dv
1 (red) Pa_4_9630 PaTOR (11) 4 / 2 6 TOR1: ne; TOR2: e
2 (green) Pa_1_20610 PaATG3 (13) 3 / 6 9 ne, aa, dv
6 (ocher) Pa_3_7690 PaYPT1 (9) 9 / 3 12 e
2 (green) Pa_1_14210 PaATG11 (9) 8 / 8 16 ne, ma
3 (turquois) Pa_4_7460 PaATG12 (10) 5 / 12 17 ne, aa, dv
6 (ocher) Pa_5_4470 PaTRS130 (10) 6 / 13 19 e
2 (green) Pa_5_5670 PaSEC24 (7) 16 / 9 25 e
2 (green) Pa_7_10890 PaATG1 (6) 22 / 5 27 ne, aa, dv
  1. The first column gives the module and its color according to Fig. 3. The column “Ranks” gives the ranks based on the degree and the betweenness. We summed up both values to a total rank and sort the table in descending order. The last column gives the most important effects on the yeast strain where the corresponding homologous gene had been knocked out [7]. Abbreviations: ne=non-essential, aa=autophagy absent, dv=decreased viability, e=essential, ma=mitophagy absent. For PaTOR, two homologs exist, TOR1 and TOR2. The protein identifiers were adopted from the P. anserina genome database [10]