Table 1 The co-functional miRNA pairs and their potential co-functional targets for both cancers and non-cancer diseases
Cancer related co-functional miRNA pairs | ||||
miRNA1 | miRNA2 | Rank | Cancer numbers | Co-functional targets |
miR-15a-5p | miR-15b-5p | 8 | 37 | BCL2; CDKN1A; CCND1; VEGFA; MTHFR; IFNG; FGF2; FGFR4; SMAD7; CHEK1 |
miR-17-5p | miR-20a-5p | 1 | 50 | TP53; CCND1; BCL2; CDKN1A; MDM2; VEGFA; MYC; HIF1A; CXCL8; SOD2 |
miR-29a-3p | miR-29b-3p | 19 | 27 | BCL2; MDM2; VEGFA; CASP8; MMP2; PTEN; AKT2; SPARC; VHL; DNMT3B |
miR-29a-3p | miR-29c-3p | 10 | 27 | BCL2; MDM2; VEGFA; CASP8; MMP2; PTEN; AKT2; SPARC; VHL; DNMT3B |
miR-29b-3p | miR-29c-3p | 13 | 29 | BCL2; MDM2; VEGFA; CASP8; MMP2; PTEN; VHL; AKT2; SPARC; CCNA2 |
Non-cancer diseases related co-functional miRNA pairs | ||||
miRNA1 | miRNA2 | Rank | Disease numbers | Co-functional targets |
miR-15a-5p | miR-15b-5p | 5 | 10 | IFNG; MTHFR; RARB; BCL2; CSNK1E; JARID2; PDCD1; ALDH3B1; APP; CDC25A |
miR-17-5p | miR-20a-5p | 2 | 17 | CXCL8; SOD2; BCL2; ESR2; TP53; VEGFA; F3; ITGA2; PTGER4; CCL5 |
miR-29a-3p | miR-29b-3p | 1 | 20 | MMP2; VEGFA; COL3A1; BCL2; FGB; CASP8; FGA; S100B; SPARC; TGFB3 |
miR-29a-3p | miR-29c-3p | 4 | 13 | MMP2; COL3A1; VEGFA; AKT2; CASP8; FGB; MDM2; SGK1; TET2; BCL2 |
miR-29b-3p | miR-29c-3p | 3 | 14 | MMP2; COL3A1; VEGFA; AKT2; CASP8; FGB; MDM2; MMP15; SGK1; MMP24 |