Table 1 Set of 36 phenotypes obtained from the listed siRNA experiments sorted by its CMPO identifier
From: Erratum to: How can functional annotations be derived from profiles of phenotypic annotations?
Experiment | Description | Phenotypes | IDs in CMPO |
|---|---|---|---|
CellMorph [3] | Genome-wide RNAi screen that examines changes in the morphology of individual HeLa cells within cell populations. | - Decreased cell number - Cell with projections - Elongated cell - More lamellipodia cells - Increased number of actin filament - Round cell - Increased cell size - Decreased cell size - Bright nuclei - Metaphase arrested - Increased cell size in population | CMPO:0000052 CMPO:0000071 CMPO:0000077 CMPO:0000083 CMPO:0000105 CMPO:0000118 CMPO:0000128 CMPO:0000129 CMPO:0000154 CMPO:0000305 CMPO:0000340 |
MitoCheck [2] | Genome-wide RNAi screen for genes required for chromosome segregation in HeLa cells. The screen also reports genes involved in other processes such as cell movement. | - Cell death - Increased nucleus size - Graped micronucleus - Abnormal nucleus shape - Mitosis delayed - Binuclear cell - Absence of mitotic chromosome decondensation - Increased cell movement speed - Increased cell movement distance - Proliferating cells - Metaphase delayed - Abnormal chromosome segregation - Prometaphase delayed - Increased variability of nuclear shape in population - Mitotic metaphase plate congression | CMPO:0000030 CMPO:0000140 CMPO:0000156 CMPO:0000157 CMPO:0000202 CMPO:0000213 CMPO:0000216 CMPO:0000236 CMPO:0000237 CMPO:0000241 CMPO:0000307 CMPO:0000326 CMPO:0000344 CMPO:0000345 CMPO:0000348 |
EMBL secretion [4] | Genome-wide RNAi screen for interference with ER-to-plasma membrane transport of the secretory cargo protein tsO45G in HeLa cells. | - Increased rate of protein secretion - Mild decrease in rate of protein secretion - Strong decrease in rate of protein secretion - Decreased rate of intracellular protein transport | CMPO:0000246 CMPO:0000318 CMPO:0000319 CMPO:0000346 |
GR00053 [10] | Genome-wide RNAi screen for genes involved in DNA damage responses in HeLa cells. | - Increased number of site of double-strand break | CMPO:0000182 |
GR00290 [9] | Genome-wide RNAi screen for genes regulating centriole formation in HeLa cells. | - Increased centriole replication - Decreased centriole replication | CMPO:0000361 CMPO:0000362 |
Copenhagen DNA damage Ubiquitin [8] | RNAi screen of >1300 genes involved in the ubiquitin-proteasome system or encoding zinc-finger proteins looking for modulators of cellular responses to ionizing radiation in HeLa and U2OS cells. | - Decreased number of site of double-strand brea | CMPO:0000181 |
EMBL chromosome condensation [7] | RNAi screen of 100 bioinformatically-selected genes for changes in mitotic prophase duration in HeLa cells. | - Increased duration of mitotic prophase - Decreased duration of mitotic prophase | CMPO:0000328 CMPO:0000329 |