Fig. 3

a Sequence logo for the CTCF binding motif. The larger the letters, the higher the fold-enrichment compared to the background distribution. b The PWM model represented as a factor graph. Note that since the nucleotides are considered independent of one another, no variable nodes are connected. c The approximations to the tail obtained from IS, SA and the method from the TFMPvalue package. d The relative difference between significance estimates from TFMPvalue and IS and SA respectively for all JASPAR Vertebrate motifs. The differences for the CTCF motif is indicated with yellow stars