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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Pan-cancer analysis of systematic batch effects on somatic sequence variations

Fig. 3

Comparison of distributions of batch-biased and unbiased variants. a. Distribution of indel types (left) and non-indel types (right) for the batch-biased variants (blue) and unbiased variants (grey). b. Distribution of GC content in each mutation type (i.e., indel–AT, indel–GC, non-indel–AT and non-indel–GC) for batch-biased variants (blue) and unbiased variants (grey). Ratio of GC content was calculated using the 20 nucleotide sequences flanking the variant sites. (* P < 0.001.) c. Distribution of mutation types according to protein function for the batch-biased and unbiased calls with indel-type (right) and non-indel–type (left) mutations. d. Distribution of genome coordinates in relation to gene position for batch-biased variants and unbiased variants. e. Distribution of mutation rate in each MAF dataset for batch-biased variants (red) and unbiased variants (black)

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