Fig. 3
From: TIGERi: modeling and visualizing the responses to perturbation of a transcription factor network
Global view of the significant changes in TF activities. Our visualization tools make it possible to distinguish specific features and trends in each condition. a The changes in TF activities underlying absence of p38α are presented in the limpet-like plots. In the upper part of the limpet plots, the TFs are placed in order of functional group (Fig. 3c). Genes that have at least one significant change are located in the bottom of the plots. A line presents how much the TF activity of a certain gene is changed between the wild-type mice and the knock-out mice. If a value of the change is greater than zero, it is displayed in blue indicating that the TF-gene pair has significantly higher TF activation in the wild-type mice (Down-regulation after deleting p38α); while, if the change is less than zero, it is displayed in red indicating that the pair has significantly higher TF activation in the knock-out mice (Up-regulation in deleting p38α). b The legend for the line color is present. c The perimeters of the plots are broken into different colored regions corresponding to different functional groups listed in the key