Fig. 4

a, b The average strength of changes in TF-gene interaction \( \mathbf{S} \) and TF concentration levels \( \mathbf{c} \) between wild-type and knock-out mice. The figures clearly show not only which TFs have strong interaction strengths or high concentrations (gray-colored TFs) but also which TFs have significant changes in their interaction pattern or concentration (blue- or red-colored TFs). The dotted lines indicate the standard deviation (=2) centered on the median value of the straight lines. (figure a for time point E13.5 and figure b for time point E15.5). Five TFs (shown in red) interact particularly strongly with their target genes in the p38α knout-mice. In contrast, six TFs (shown in blue) interact less-strongly in the p38α knock-out than wild-type. c, d The TF concentration levels 풸 of wild-type and knock-out mice. TF concentration levels are plotted. The strongest signal was observed in E13.5, only. Deleting p38α induces a down regulation of AREB6, PITX2, STAT1 and SOX9