TIGERi: modeling and visualizing the responses to perturbation of a transcription factor network

BMC Bioinformatics

Table 2 TFs showing significant changes in concentration between wild-type and knock-out mice

Trans name	TF group	Cis name	Level	GO analy-sis	Known biological functions	Ref.
AREB6	1.Dev	ZEB1	Down	-	p38 → IFNγ → ZEB1 → Immune	[58]
PITX2	1.Dev	PITX2	Down	Apo	p38 → PITX2 → Development → Apoptosis	[63, 64]
STAT1	6. Lat	STAT1	Down	-	STAT1 → Development → Immune	[57, 69]
SOX9	7. Unk	SOX9	Down	Apo, Dev	p38 → SOX9 → Apoptosis	[59,60,61,62]

TFs changing their concentration levels significantly between wild-type and knock-out mice. “Level”, the changes of TF concentration level in the absence of p38α. Other column headings and abbreviations are the same as those in Table 1
The boldface ones are the main node in Fig. 5

ISSN: 1471-2105