Fig. 1From: Drug repositioning for enzyme modulator based on human metabolite-likenessHeat map of 2D structural similarities between the FDA-approved drugs and human intermediary metabolites. The Tanimoto similarity matrix between the 1,861 drugs and 1,110 metabolites encoded by the MACCS key fingerprints. Red boxes with the A, B, and C labels indicate the highlighted clusters: > 50 drugs, > 100 metabolites, Tc  ≥ 0.7 (up to 30%)Back to article page