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Table 1 Similarity between Antimetabolites and their corresponding human metabolites

From: Drug repositioning for enzyme modulator based on human metabolite-likeness

Target Enzyme Substrate Antimetabolite Similarity P-value
TYMS dUMP Trifluridine 0.82 1.97E-03
Floxuridine 0.79 6.38E-12
Gemcitabine 0.69 2.26E-02
Capecitabine 0.66 9.54E-03
5,10-Methylene-
tetrahydrofolate
Pemetrexed 0.75 3.85E-04
Raltitrexed 0.75 8.57E-10
Pralatrexate 0.69 1.40E-09
POLA1,POLB dATP Cladribine 0.77 1.76E-08
Clofarabine 0.72 6.50E-07
Fludarabine 0.71 1.94E-06
dGTP Nelarabine 0.76 3.38E-09
dCTP Cytarabine 0.75 7.13E-52
DHFR 7,8-Dihydrofolate Pemetrexed 0.86 7.40E-05
(6S)-5,6,7,8-tetra-
hydrofolate(2-)
Pralatrexate 0.82 6.48E-22
Methotrexate 0.78 1.88E-05
RRM1 ADP Fludarabine 0.8 2.28E-08
Clofarabine 0.73 5.95E-05
Cladribine 0.71 1.59E-02
CDP Gemcitabine 0.77 6.06E-03
DNMT1 Cytidine Azacitidine 0.97 6.01E-17
Decitabine 0.88 8.06E-12
IMPDH1/2 IMP Ribavirin 0.69 2.66E-05
ENPP1 Deamino-NAD+ Ribavirin 0.69 1.02E-06
ATIC 10-Formyl-
tetrahydrofolate
Pemetrexed 0.79 7.73E-06
GART Pemetrexed 0.79 7.73E-06
NME1/2 dCDP Gemcitabine 0.76 1.37E-10
XDH Hypoxanthine Allopurinol 0.69 7.90E-12