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Table 1 Comparison of multifunctional genes from FCM gene-sets and KEGG pathways. Multifunctional genes that were involved in at least 3 FCM DC gene-sets were also overlapping between KEGG pathways

From: Meta-analysis of cell- specific transcriptomic data using fuzzy c-means clustering discovers versatile viral responsive genes

Multifunctional genes

No. of pathways

No. of FCM DC clusters

Enriched pathway names

FCM cluster

NFATC4

5

5

MAPK_SIGNALING, VEGF_SIGNALING, NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY, T_CELL_RECEPTOR_SIGNALING, B_CELL_RECEPTOR_SIGNALING

34,35,37,43,45

CCL23

2

4

CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION, CHEMOKINE_SIGNALING_PATHWAY

17,18,39,40

GAB2

2

4

FC_EPSILON_RI_SIGNALING, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS

13,16,19,31

IL21R

2

4

CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION, JAK_STAT_SIGNALING

7,8,20,24

VASP

2

4

FOCAL_ADHESION, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS

1,4,10,50

ANAPC1

2

3

CELL_CYCLE, UBIQUITIN_MEDIATED_PROTEOLYSIS

7,8,29

ASAP1

2

3

ENDOCYTOSIS, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS

30,31,39

CCND2

3

3

CELL_CYCLE, FOCAL_ADHESION, JAK_STAT_SIGNALING

7,14,29

CD80

4

3

CELL_ADHESION_MOLECULES_CAMS, TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY, INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION, ISGs

36,45,46

CDC16

2

3

CELL_CYCLE, UBIQUITIN_MEDIATED_PROTEOLYSIS

8,14,29

CDK4

2

3

CELL_CYCLE, T_CELL_RECEPTOR_SIGNALING

23,33,44

DNM2

2

3

ENDOCYTOSIS, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS

3,12,31

EP300

3

3

JAK_STAT_SIGNALING, CELL_CYCLE, TGF_BETA_SIGNALING,

3,4,50

HSPB1

2

3

MAPK_SIGNALING, VEGF_SIGNALING

5,25,50

IL1R2

3

3

MAPK_SIGNALING, CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION, HEMATOPOIETIC_CELL_LINEAGE

6,21,22

ITGAV

2

3

FOCAL_ADHESION, CELL_ADHESION_MOLECULES_CAMS

2,25,50

MAP3K1

3

3

MAPK_SIGNALING_PATHWAY, UBIQUITIN_MEDIATED_PROTEOLYSIS, RIG_I_LIKE_RECEPTOR_SIGNALING

1,27,50

POLR1C

2

3

RNA_POLYMERASE, CYTOSOLIC_DNA_SENSING

3,31,33

PPP3CB

6

3

MAPK_SIGNALING, APOPTOSIS, VEGF_SIGNALING, NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY, T_CELL_RECEPTOR_SIGNALING, B_CELL_RECEPTOR_SIGNALING

16,28,29

RPS6KB1

4

3

ERBB_SIGNALING, MTOR_SIGNALING, TGF_BETA_SIGNALING, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS

16,23,28

TNFRSF1A

3

3

MAPK_SIGNALING, CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION, APOPTOSIS

5,25,50

WAS

2

3

CHEMOKINE_SIGNALING, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS

23,28,44

PIK3R1

14

3

T CELL RECEPTOR SIGNALING, B CELL RECEPTOR SIGNALING, TOLL LIKE RECEPTOR SIGNALING and 11 others

7,8,24