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Table 1 Comparison of multifunctional genes from FCM gene-sets and KEGG pathways. Multifunctional genes that were involved in at least 3 FCM DC gene-sets were also overlapping between KEGG pathways

From: Meta-analysis of cell- specific transcriptomic data using fuzzy c-means clustering discovers versatile viral responsive genes

Multifunctional genes No. of pathways No. of FCM DC clusters Enriched pathway names FCM cluster
NFATC4 5 5 MAPK_SIGNALING, VEGF_SIGNALING, NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY, T_CELL_RECEPTOR_SIGNALING, B_CELL_RECEPTOR_SIGNALING 34,35,37,43,45
CCL23 2 4 CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION, CHEMOKINE_SIGNALING_PATHWAY 17,18,39,40
GAB2 2 4 FC_EPSILON_RI_SIGNALING, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 13,16,19,31
IL21R 2 4 CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION, JAK_STAT_SIGNALING 7,8,20,24
VASP 2 4 FOCAL_ADHESION, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 1,4,10,50
ANAPC1 2 3 CELL_CYCLE, UBIQUITIN_MEDIATED_PROTEOLYSIS 7,8,29
ASAP1 2 3 ENDOCYTOSIS, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 30,31,39
CCND2 3 3 CELL_CYCLE, FOCAL_ADHESION, JAK_STAT_SIGNALING 7,14,29
CD80 4 3 CELL_ADHESION_MOLECULES_CAMS, TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY, INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION, ISGs 36,45,46
CDC16 2 3 CELL_CYCLE, UBIQUITIN_MEDIATED_PROTEOLYSIS 8,14,29
CDK4 2 3 CELL_CYCLE, T_CELL_RECEPTOR_SIGNALING 23,33,44
DNM2 2 3 ENDOCYTOSIS, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 3,12,31
EP300 3 3 JAK_STAT_SIGNALING, CELL_CYCLE, TGF_BETA_SIGNALING, 3,4,50
HSPB1 2 3 MAPK_SIGNALING, VEGF_SIGNALING 5,25,50
IL1R2 3 3 MAPK_SIGNALING, CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION, HEMATOPOIETIC_CELL_LINEAGE 6,21,22
ITGAV 2 3 FOCAL_ADHESION, CELL_ADHESION_MOLECULES_CAMS 2,25,50
MAP3K1 3 3 MAPK_SIGNALING_PATHWAY, UBIQUITIN_MEDIATED_PROTEOLYSIS, RIG_I_LIKE_RECEPTOR_SIGNALING 1,27,50
POLR1C 2 3 RNA_POLYMERASE, CYTOSOLIC_DNA_SENSING 3,31,33
PPP3CB 6 3 MAPK_SIGNALING, APOPTOSIS, VEGF_SIGNALING, NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY, T_CELL_RECEPTOR_SIGNALING, B_CELL_RECEPTOR_SIGNALING 16,28,29
RPS6KB1 4 3 ERBB_SIGNALING, MTOR_SIGNALING, TGF_BETA_SIGNALING, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 16,23,28
TNFRSF1A 3 3 MAPK_SIGNALING, CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION, APOPTOSIS 5,25,50
WAS 2 3 CHEMOKINE_SIGNALING, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 23,28,44
PIK3R1 14 3 T CELL RECEPTOR SIGNALING, B CELL RECEPTOR SIGNALING, TOLL LIKE RECEPTOR SIGNALING and 11 others 7,8,24