Fig. 6
From: Simple adjustment of the sequence weight algorithm remarkably enhances PSI-BLAST performance
Schematic representation of narrow-width block generation by HOE. When we performed a PSI-BLAST search [22], at the NCBI website, of a protein sequence (UniProtKB [23] accession number: Q5JHS2, as a query) that contains two conserved domains (Pfam [10] IDs: PF13419 and PF00535) against the UniProtKB/Swiss-Prot database [24], we found that a hit (UniProtKB accession number: Q9S586) consisting of a single-domain protein (Pfam ID: PF13419) with HOE (white boxes) has an overlap with another hit (UniProtKB accession number: A2E3C6) matched only to the domain of PF00535, resulting in a 3 aa-long block (gray bar)