Fig. 4
From: AGeNNT: annotation of enzyme families by means of refined neighborhood networks
rGNN of IPR015890 (chorismate-utilizing enzymes, C-terminal domain). The family of chorismate-utilizing enzymes comprises several homologous but functionally diverse enzymes from different primary and secondary metabolic pathways. The enzyme AS from tryptophan biosynthesis is represented by cluster-nodes 38 and 59, whose GN represents the typical tryptophan operon. The GN of ADCS from folate biosynthesis (cluster-node 64) is less conserved and consists of one Pfam-node, representing the enzyme catalyzing the subsequent step of folate biosynthesis. The homologous ICS and SS enzymes are part of different biosynthesis pathways that lead to iron-chelating siderophores as well as electron transport compounds. The rGNN greatly assists in separating these enzymes into different isofunctional groups: The GNs make clear that cluster-nodes 20, 36, and 19 represent MenF-type ICS, cluster-node 43 represents EntC-type ICS, and cluster-node 33 represents SS enzymes