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Table 1 AUC, Youden index (J), Sensitivity (Se) and Specificity (Sp) from the 3-way cross validation within dataset 1 (ribosomal genes)

From: A systematic evaluation of nucleotide properties for CRISPR sgRNA design

Feature class

AUC

J

Se

Sp

PD Mono

0.826

0.535

0.855

0.680

PD Dinuc

0.848

0.575

0.788

0.787

Freq

0.778

0.441

0.677

0.764

Align

0.613

0.188

0.746

0.442

Thermo

0.525

0.086

0.812

0.273

Packer

0.601

0.186

0.634

0.551

PhyChem

0.722

0.380

0.711

0.669

PseKNC

0.731

0.376

0.683

0.693

Comb Feature

0.867

0.618

0.826

0.792

  1. Comb Feature: PD Mono+PD Dinuc+Freq+Thermo+Packer+PhyChem+PseKNC. We reported the average performance from the 3-way cross validation over 10 iterations of random sampling
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BMC Bioinformatics

ISSN: 1471-2105

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