Fig. 11

Performance of the epigenomics algebra on ESC gene markers. a Heatmap of the scaled ranking s(r) calculated by Eq. 6 for the SEs predicted by different S T I T _{p r e d−a l g e b r a} for ESC gene markers. The scaled ranking is colour coded in log₁₀ scale, in red for good ranked (low ranking values) SEs, in yellow (from 2.0 onwards) for good ranked TEs, in green and blue for bad ranked TEs, and in grey for TEs without signal prediction. b Global goodness of each S T I T _{p r e d−a l g e b r a} over the whole set of ESC gene markers; normalised to the predictor of highest average (HOMER H3K4me3). Epigenomic algebra and single epigenomic signal box plot of peak distribution, depicted by our GVT module, for the SE associated to NANOG (c) and FOXO1 (d). The bottom row contains the combination of epigenomic signals, and the rows above contain the original single signals. Black lines below the signal represent the SE supports at each sample, and bars in alternating colours below SE bar show the supports of the SE subpeak composition