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Table 2 Summary of the 40 T4 mutant structure

From: 3D deep convolutional neural networks for amino acid environment similarity analysis

Variant

Mutant PDB ID

Effect

Source

G77A

1 L23

Neutral

[64]

A82P

1 L24

Neutral

[64]

A93T

129 L

Neutral

[65]

T151S

130 L

Neutral

[65]

T26S

131 L

Neutral

[65]

V149 M

1CV6

Neutral

[66]

V87 M

1CU3

Destabilizing

[66]

S38 N

1 L61

Neutral

[67]

T109 N

1 L59

Neutral

[67]

T109D

1 L62

Neutral

[67]

N116D

1 L57

Neutral

[67]

D92N

1 L55

Destabilizing

[67]

S38D

1 L19

Neutral

[68]

N144D

1 L20

Neutral

[68]

M106I

1P46

Neutral

[69]

M120Y

1P6Y

Neutral

[69]

V149I

1G0Q

Neutral

[70]

T152 V

1G0L

Neutral

[70]

V149S

1G06

Destabilizing

[70]

V149C

1G07

Destabilizing

[70]

V149G

1G0P

Destabilizing

[70]

E108V

1QUG

Neutral

[71]

L99G

1QUD

Destabilizing

[71]

S117F

1TLA

Neutral

[72]

M106 L

234 L

Neutral

[73]

M120 L

233 L

Neutral

[73]

M106 K

231 L

Destabilizing

[73]

M120 K

232 L

Destabilizing

[73]

I3V

1 L17

Neutral

[74]

I3Y

1 L18

Destabilizing

[74]

M102 K

1 L54

Destabilizing

[75]

T157I

1 L10

Destabilizing

[76]

G156D

1 L16

Destabilizing

[77]

R96H

1 L34

Destabilizing

[78]

I3P

1 L97

Destabilizing

[79]

R96N

3CDT

Destabilizing

[80]

R96D

3C8Q

Destabilizing

[80]

R96W

3FI5

Destabilizing

[80]

R96Y

3C80

Destabilizing

[80]

M102 L

1 L77

Destabilizing

[81]

  1. Forty available T4 lysozyme mutant structures were collected and categorized for their effects. Each mutant is classified based on the literature, where a stabilizing mutation is categorized as “neutral” and a destabilizing mutation is categorized as “destabilizing”