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Table 2 Summary of the 40 T4 mutant structure

From: 3D deep convolutional neural networks for amino acid environment similarity analysis

Variant Mutant PDB ID Effect Source
G77A 1 L23 Neutral [64]
A82P 1 L24 Neutral [64]
A93T 129 L Neutral [65]
T151S 130 L Neutral [65]
T26S 131 L Neutral [65]
V149 M 1CV6 Neutral [66]
V87 M 1CU3 Destabilizing [66]
S38 N 1 L61 Neutral [67]
T109 N 1 L59 Neutral [67]
T109D 1 L62 Neutral [67]
N116D 1 L57 Neutral [67]
D92N 1 L55 Destabilizing [67]
S38D 1 L19 Neutral [68]
N144D 1 L20 Neutral [68]
M106I 1P46 Neutral [69]
M120Y 1P6Y Neutral [69]
V149I 1G0Q Neutral [70]
T152 V 1G0L Neutral [70]
V149S 1G06 Destabilizing [70]
V149C 1G07 Destabilizing [70]
V149G 1G0P Destabilizing [70]
E108V 1QUG Neutral [71]
L99G 1QUD Destabilizing [71]
S117F 1TLA Neutral [72]
M106 L 234 L Neutral [73]
M120 L 233 L Neutral [73]
M106 K 231 L Destabilizing [73]
M120 K 232 L Destabilizing [73]
I3V 1 L17 Neutral [74]
I3Y 1 L18 Destabilizing [74]
M102 K 1 L54 Destabilizing [75]
T157I 1 L10 Destabilizing [76]
G156D 1 L16 Destabilizing [77]
R96H 1 L34 Destabilizing [78]
I3P 1 L97 Destabilizing [79]
R96N 3CDT Destabilizing [80]
R96D 3C8Q Destabilizing [80]
R96W 3FI5 Destabilizing [80]
R96Y 3C80 Destabilizing [80]
M102 L 1 L77 Destabilizing [81]
  1. Forty available T4 lysozyme mutant structures were collected and categorized for their effects. Each mutant is classified based on the literature, where a stabilizing mutation is categorized as “neutral” and a destabilizing mutation is categorized as “destabilizing”