Fig. 1

Performance comparison of Standard Search Matrices with PFASUM Search Matrices of similar entropies on all three ASTRAL datasets. The highest achieved coverage at an 0.01 errors per query for any gap opening and extension penalty combination is shown. Best performing gap parameter for each matrix and database combination can be found in Additional file 6: Table S2. Please note, we reduced the shown range of the coverage to emphasize the differences between the matrices