Fig. 1
From: Biomarker correlation network in colorectal carcinoma by tumor anatomic location
Biomarker networks by tumor location; proximal colon cancer network (a), and distal colorectal cancer network (b). A node represents a molecular feature, and an edge specifies a statistically significant Spearman correlation between two markers (nodes) with a significance level of 3.5 × 10−5 (0.05/1431, based on the Bonferroni correction). The red line indicates a positive correlation, and the blue line indicates a negative correlation; line width is proportional to correlation coefficient. CDKN2A (IHC), protein expression of CDKN2A; CDKN2A, methylation level of CDKN2A; LINE-1, methylation level of long interspersed nucleotide element 1; MSI, microsatellite instability; TIL, lymphocytes on top of neoplastic epithelial cells