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Table 3 Network characteristics by tumor location

From: Biomarker correlation network in colorectal carcinoma by tumor anatomic location

  Total (N = 1380) Proximal colon cancer (N = 690) Distal colorectal cancer (N = 690)
Correlation network based on original variables
 Number of nodes 54 54 54
 Number of edges 268 173 95
 Median degree 8.0 3.0 2.0
 Average clustering coefficient 0.52 0.50 0.30
 Hubsa (degree centrality) RUNX3 (0.47)
CACNA1G (0.45)
MSI (0.45)
MLH1 (0.43)
TIL (0.43)
BRAF (0.40)
NEUROG1 (0.40)
CRABP1 (0.38)
IGF2 (0.38)
SOCS1 (0.38)
CDKN2A b (0.36)
MIR155 (0.36)
MSI (0.39)
MLH1 (0.36)
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Correlation network in non-MSI-high cancer
 Number of nodes 53 53 53
 Median degree 4.0 1.0 1.0
 Number of edges 120 64 56
 Average clustering coefficient 0.33 0.23 0.26
 Hubsa (degree centrality) RUNX3 (0.15)
NEUROG1 (0.15)
BRAF (0.19)
CDKN2A b (0.17)
IGF2 (0.17)
RUNX3 (0.17)
CACNA1G (0.15)
CRABP1 (0.15)
NEUROG1 (0.15)
RUNX3 (0.15)
NEUROG1 (0.15)
Correlation network based on the same number of edges
 Number of nodes 54 54 54
 Median degree 1.5 4.0 1.0
 Number of edges 100 100 100
 Average clustering coefficient 0.27 0.29 0.27
 Hubsa (degree centrality) CACNA1G (0.26)
IGF2 (0.26)
RUNX3 (0.25)
BRAF (0.23)
MLH1 (0.23)
MSI (0.23)
CRABP1 (0.21)
TIL (0.21)
CDKN2A b (0.19)
NEUROG1 (0.19)
SOCS1 (0.19)
CACNA1G (0.28)
MLH1 (0.26)
MSI (0.26)
IGF2 (0.25)
RUNX3 (0.25)
BRAF (0.23)
CRABP1 (0.23)
CDKN2A b (0.21)
TIL (0.21)
NEUROG1 (0.19)
SOCS1 (0.17)
RUNX3 (0.19)
IGF2 (0.17)
NEUROG1 (0.17)
  1. aMarkers with degree centrality at or above the 80th percentile in the colorectal cancer network
  2. b CDKN2A promoter hypermethylation
  3. MSI microsatellite instability, TIL Tumor infiltrating lymphocytes