TY - JOUR AU - Tripathi, Shailesh AU - Lloyd-Price, Jason AU - Ribeiro, Andre AU - Yli-Harja, Olli AU - Dehmer, Matthias AU - Emmert-Streib, Frank PY - 2017 DA - 2017/07/04 TI - sgnesR: An R package for simulating gene expression data from an underlying real gene network structure considering delay parameters JO - BMC Bioinformatics SP - 325 VL - 18 IS - 1 AB - sgnesR (Stochastic Gene Network Expression Simulator in R) is an R package that provides an interface to simulate gene expression data from a given gene network using the stochastic simulation algorithm (SSA). The package allows various options for delay parameters and can easily included in reactions for promoter delay, RNA delay and Protein delay. A user can tune these parameters to model various types of reactions within a cell. As examples, we present two network models to generate expression profiles. We also demonstrated the inference of networks and the evaluation of association measure of edge and non-edge components from the generated expression profiles. SN - 1471-2105 UR - https://doi.org/10.1186/s12859-017-1731-8 DO - 10.1186/s12859-017-1731-8 ID - Tripathi2017 ER -