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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Integrated genomic analysis of biological gene sets with applications in lung cancer prognosis

Fig. 1

A general overview of the variance component-based total effect gene set testing procedure. Each gene within a gene set of interest has at least two sources of genomic data such as DNAm and mRNA expression per subject. Two levels of integration occur, first at the single-gene level to jointly test DNAm and mRNA expression, then at the network level where the evidence from all viable genes is jointly assessed to produce a test of the gene set. Q ̂: observed Q-statistics; \(\{\hat {Q}_{*}^{(b)}\}\): the resampling-based perturbation distribution for \(\hat {Q}_{*}\) under the null

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