Fig. 1From: Integrated genomic analysis of biological gene sets with applications in lung cancer prognosisA general overview of the variance component-based total effect gene set testing procedure. Each gene within a gene set of interest has at least two sources of genomic data such as DNAm and mRNA expression per subject. Two levels of integration occur, first at the single-gene level to jointly test DNAm and mRNA expression, then at the network level where the evidence from all viable genes is jointly assessed to produce a test of the gene set. Q ̂∗: observed Q-statistics; \(\{\hat {Q}_{*}^{(b)}\}\): the resampling-based perturbation distribution for \(\hat {Q}_{*}\) under the nullBack to article page