Fig. 1From: Quantification of tumour evolution and heterogeneity via Bayesian epiallele detection a An example of a genomic locus (chr1:1,145,478-1,145,614) in which each row corresponds to a sequencing read. Black and white circles represent methylated and unmethylated CpGs respectively. Note that some CpG measurements are missing. b The four epialleles that are inferred from the observed sequencing reads. c The Akaike Information Criterion score versus the total number of epialleles. The inferred number of epialleles corresponds to the minimum AIC score. d The proportion of observed reads attributed to each epiallele after marginalisation over the parameter w (see main text for details)Back to article page