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Fig. 10 | BMC Bioinformatics

Fig. 10

From: CRISPulator: a discrete simulation tool for pooled genetic screens

Fig. 10

Effect of bin size on signal and noise of FACS-based screens. For FACS-based screens, the effect of the size of the sorted bins (see Fig. 1) on metrics for signal, noise, and signal-to-noise ratio (scaled within each plot) is shown. Metrics are defined in the Implementation section. Simulations were run for 100× representation (top row) or 1000× representation (bottom row) at the transfection, bottleneck and sequencing stages. Lines and light margins represent means and 99% confidence intervals, respectively, for 25 independent simulation runs

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