Fig. 3
From: Correcting nucleotide-specific biases in high-throughput sequencing data
Aggregate stacked nucleotide pileups are shown across all reads within 250bp of known CTCF binding sites. DNase-seq data from GM12878 before and after bias correction are shown in (a) and (b), respectively. c and d show the cut profile on deproteinized “naked” K562 DNA before and after bias correction. In both cases, correction of nucleotide-specific bias removed spurious bias-driven spikes, smoothing the CTCF footprint (b) and restoring uniform coverage (d)