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Table 1 Average nucleotide variance before and after correction

From: Correcting nucleotide-specific biases in high-throughput sequencing data

 

DNase-seq

FAIRE-seq

ChIP-seq

ATAC-seq

Raw data

0.022

0.006

0.005

0.023

Bias corrected

0.009

0.005

0.003

0.008

  1. Variance before correction is especially high in DNase-seq and ATAC-seq as a result of DNase I and Tn5 binding preference, respectively