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Fig. 6 | BMC Bioinformatics

Fig. 6

From: CIPHER: a flexible and extensive workflow platform for integrative next-generation sequencing data analysis and genomic regulatory element prediction

Fig. 6

Definition of enhancer states and validation of enhancer-prediction model. a Enhancer states and their corresponding chromatin signatures, DNase hypersensitive sites (DHS), and eRNA levels. Red and blue indicate sense and antisense eRNAs, respectively. b Heat maps of DNase, H3K4me1, H3K27ac, H3K4me3, and GRO-seq (red: sense eRNAs, blue: antisense eRNAs) signal at active enhancers centered on the middle of all enhancers and extended 3 Kb in either direction. c Heat maps of DNase, H3K4me1, H3K27ac, H3K4me3, and GRO-seq (red: sense eRNAs, blue: antisense eRNAs) signal at primed enhancers centered on the middle of all enhancers and extended 3 Kb in either direction. d Genome browser view of predicted enhancers and their associated genome features. e Heat maps of HeLa active enhancers centered on the middle of all enhancers and extended 3 Kb in either direction. f Heat maps of HeLa primed enhancers centered on the middle of all enhancers and extended 3 kb in either direction

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BMC Bioinformatics

ISSN: 1471-2105

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