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Table 2 Median values, [interquartile ranges (sample size)] and Mann-Whitney U test p-values (uncorrected and Bonferroni corrected (BF)) to test for association between 14 self-reported conditions and the number heteroplasmic variants (HF > 0.3) present in the Wellderly cohort

From: SG-ADVISER mtDNA: a web server for mitochondrial DNA annotation with data from 200 samples of a healthy aging cohort

 

Yes

No

Mann-Whitney U test

Mann-Whitney U test

Condition

Median [IQR (n)]

Median [IQR (n)]

p-value

p-value (BF)

Blad_control

7.0 [5–8 (6)]

7.0 [5–10 (192)]

0.5974

1.0000

Bph

7.0 [3–9 (24)]

7.0 [5–9 (174)]

0.7815

1.0000

Copd_asthma

6.0 [3–9 (7)]

7.0 [5–9 (193)]

0.4505

1.0000

Depr_anx

7.0 [3–9 (12)]

7.0 [5–9 (188)]

0.5750

1.0000

Dyslipidemia

8.0 [6–12 (46)]

7.0 [4–9 (154)]

0.0833

1.0000

Gerd

7.0 [6–9 (19)]

7.0 [5–9 (181)]

0.4879

1.0000

Glaucoma

7.0 [4–11 (30)]

7.0 [5–9 (170)]

0.8320

1.0000

Hrt

8.5 [7–10 (12)]

7.0 [5–9 (188)]

0.0682

0.9549

Hyperten

7.5 [5–10 (80)]

7.0 [4–9 (120)]

0.0399

0.5585

Hypothyroid

7.0 [5–10 (39)]

7.0 [5–9 (161)]

0.7091

1.0000

Macular_degen

7.0 [5–9 (15)]

7.0 [5–9 (185)]

0.9132

1.0000

Osteoarth

7.0 [5–10 (87)]

7.0 [5–9 (113)]

0.3987

1.0000

Smoking_hist

7.0 [4–9 (89)]

7.0 [5–10 (111)]

0.1922

1.0000

Take_meds

7.0 [5–9 (161)]

7.0 [5–9 (39)]

0.7356

1.0000

  1. Labels: Blad_control: Bladder control problems; Bph: Benign prostatic hyperplasia; Depr_anx: Depression or anxiety; Gerd: Gastroesophageal reflux disease; Hrt: Hormone replacement therapy, Hyperten: Hypertension; Macular_degen: Macular degeneration; Osteoarth: Osteoarthritis; Smoking_hist: Smoking history; Take_meds: Currently taking medications