Table 11 The result of interactome analysis for CATH candidate domains in different cancer types
Proteins with at least one CATH candidate domain | |||||
|---|---|---|---|---|---|
Cancer type | #Nods | #Edges | Expected number of edges | PPI enrichment p-value | Significant or not |
BRCA | 315 | 1136 | 261 | 0 | YES |
COAD | 377 | 1325 | 363 | 0 | YES |
GBM | 28 | 61 | 9 | 0 | YES |
KIRC | 49 | 37 | 13 | 1.62E-08 | YES |
KIRP | 110 | 199 | 57 | 0 | YES |
LGG | 21 | 26 | 4 | 2.55E-13 | YES |
LUAD | 588 | 2173 | 652 | 0 | YES |
OV | 6 | 3 | 0 | 0.000256 | YES |
UCEC | 449 | 2159 | 671 | 0 | YES |
ACC | 15 | 1 | 0 | 0.152 | YES |
BLCA | 648 | 3067 | 1487 | 0 | YES |
CHOL | 39 | 21 | 6 | 4.84E-06 | YES |
ESCA | 191 | 703 | 180 | 0 | YES |
HNSC | 370 | 1322 | 366 | 0 | YES |
KICH | 18 | 15 | 2 | 7.81E-10 | YES |
LIHC | 307 | 1065 | 292 | 0 | YES |
LUSC | 154 | 177 | 40 | 0 | YES |
PAAD | 249 | 610 | 231 | 0 | YES |
PCPG | 56 | 35 | 10 | 5.99E-10 | YES |
PRAD | 113 | 249 | 72 | 0 | YES |
READ | 116 | 285 | 68 | 0 | YES |
SARC | 285 | 902 | 223 | 0 | YES |
SKCM | 281 | 498 | 145 | 0 | YES |
STAD | 575 | 2181 | 762 | 0 | YES |
TGCT | 78 | 91 | 9 | 0 | YES |
THCA | 91 | 248 | 136 | 0 | YES |
THYM | 146 | 411 | 83 | 0 | YES |
UCS | 22 | 15 | 6 | 0.00156 | YES |
UVM | 13 | 3 | 1 | 0.186 | NO |
Pan-cancer | 457 | 1821 | 610 | 0 | YES |