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Table 1 ANN topologies and filtering parameters for highest observed accuracies for the various ARVs

From: Improving fold resistance prediction of HIV-1 against protease and reverse transcriptase inhibitors using artificial neural networks

ARVs

Topology

Number of unique sequence IDs/expanded sequences

Number of allowed combinations

Rare variant filtering

Number of outliers removed

PIs

ATV

10x8x6

995 / 13,625

< 1000

1

DRV

8 × 8

590 / 10,374

< 1000

2

FPV

8x8x8

1429 / 17,501

< 1000

x

none

IDV

8x6x10

1459 / 16,977

< 1000

1

LPV

10x8x10

1284 / 11,019

< 300

x

none

NFV

10x10x10

1524 / 11,929

< 300

x

none

SQV

10x10x8

1484 / 11,509

< 300

x

none

TPV

10x6x8

698 / 11,989

< 1000

2

NRTIs

3TC

10x10x6

1342 / 33,181

< 1000

none

ABC

14

1401 / 34,016

< 1000

x

none

AZT

19

1358 / 33,818

< 1000

none

D4T

10x4x4

1365 / 34,056

< 1000

none

DDI

10x6x6

1368 / 34,062

< 1000

none

TDF

10 × 2

1130 / 29,637

< 1000

x

none

NNRTIs

EFV

10x6x10

1400 / 33,906

< 1000

none

ETR

8x2x10

448 / 11,397

< 1000

x

2

NVP

10x10x4

1414 / 20,348

< 300

x

none

RPV

16

169 / 2977

< 1000

none