Fig. 4

CellNetVis interface showing the human MAPK signaling pathway distributed in a cell diagram. a Visualization of the first neighbors network queried from IIS platform using 257 proteins annotated to the human MAPK signaling pathway from KEGG database as input. The nodes’ colors were set to be displayed according to the “Selected CC” attribute. The attributes of MAP3K6 are shown on the table on the right side of the diagram. b The nodes’ colors were set to be displayed according to the “[degree]” attribute. The force-directed algorithm was stopped. c Edge bundling wa computed and displayed. d The node with the darkest color, EGFR, was selected. The highlighted nodes correspond to the EGFR’s first neighbors, after EGFR’s node selection. e Only highlighted nodes are visible and force-directed layout was restarted. Organelles were moved to improve the layout