Table 4 Summary of interactions computed by VERMONT for mutations (nsSNPs) in the p53 (PDBid 1TSR) core domain that were experimentally characterized
From: Vermont: a multi-perspective visual interactive platform for mutational analysis
| Â | Aromatic stacking | Charged attractive | Charged repulsive | Disulfide bridge | Hydrogen bond | Hydrophobic | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  | μ | σ | μ | σ | μ | σ | μ | σ | μ | σ | μ | σ |
Arg273His | 1.00 | 0.00 | 6.79 | 1.51 | 1.72 | 1.00 | 0.00 | 0.00 | 4.49 | 0.85 | 1.00 | 0.00 |
Gly245Ser | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.90 | 0.61 | 1.00 | 0.00 |
Arg249Ser | 0.00 | 0.00 | 3.56 | 0.68 | 1.20 | 0.76 | 0.00 | 0.00 | 5.09 | 1.46 | 1.44 | 0.50 |
Arg248Ala | 0.00 | 0.00 | 1.00 | 0.00 | 2.13 | 0.88 | 0.00 | 0.00 | 3.04 | 0.50 | 0.00 | 0.00 |
Cys242Ser | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.98 | 0.59 | 1.00 | 0.00 |
His168Arg | 0.00 | 0.00 | 1.23 | 0.82 | 1.21 | 0.84 | 0.00 | 0.00 | 3.97 | 1.01 | 1.07 | 0.30 |
Val143Ala | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.92 | 0.31 | 1.16 | 0.40 |
Ile195Thr | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 2.07 | 0.89 |