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Fig. 2 | BMC Bioinformatics

Fig. 2

From: Investigating MicroRNA and transcription factor co-regulatory networks in colorectal cancer

Fig. 2

Graphical representations of three types of CRC-specific regulatory subnetworks. a) miRNA-SNW. This subnetwork was constructed by miRNA-FFLs, including three types of regulatory relationships: miRNA-TF, miRNA-Gene, TF-Gene. b) TF-SNW. The subnetwork was constructed by TF-FFLs, including three types of regulatory relationships: TF-miRNA, TF-Gene, miRNA-Gene. c) composite-SNW. This subnetwork was constructed by composite-FFLs, including four types of regulatory relationships: TF-miRNA, miRNA-TF, TF-Gene, miRNA-Gene. In three subnetworks, the node colors represent different molecules: red for CRC-related miRNAs, blue for transcription factors, and green for CRC-related genes. Edges in red correspond to the repression of miRNAs to genes or TFs, and edges in blue correspond to the regulation of TFs to genes or miRNAs. Scatter plots below the networks show the degree distributions of all nodes in 3 kinds of CRC-specific regulatory networks

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