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Table 10 The genes amongst the top 20 that are known to be cancer genes and their roles in the various processes required for cellular function

From: Using machine learning algorithms to identify genes essential for cell survival

Functional Class

AKT1

TP53

CDH1

CCND1

BCL2

CDKN1A

MYC

EGFR

JUN

Cell cycle

X

X

 

X

X

X

X

X

 

Cell motility and interactions

  

X

    

X

 

Cell response to stimuli

X

X

 

X

X

X

   

Cellular metabolism

X

X

 

X

 

X

X

X

X

Cellular processes

X

X

X

X

X

  

X

X

Development

X

X

 

X

X

X

 

X

X

DNA/RNA metabolism and transcription

 

X

    

X

 

X

Immune system response

X

   

X

X

   

Multicellular activities

X

   

X

    

Regulation of intracellular processes and metabolism

X

X

X

X

X

X

X

X

X

Regulation of transcription

X

X

    

X

 

X

Signal transduction

X

X

 

X

X

X

 

X

 
  1. X: genes involved in that particular functional process of the cell